Both teams make four changes from their wins over North Macedonia and Malta respectively on Friday.
Yukhym Konoplia, Oleksandr Svatok, Taras Stepanenko and Viktor Tsygankov replace Oleksandr Karavaev, Mykola Matviyenko, Serhii Sydorchuk and Vladyslav Vanat in the Ukraine XI.
For Italy, Giovanni Di Lorenzo, Alessandro Buongiorno, Davide Frattesi and Nicolo Zaniolo replace Matteo Darmian, Federico Gatti, Giacomo Bonaventura and Domenico Berardi.
Ukraine (possible 4-1-2-3) Trubin; Konoplia, Svatok, Zabarnyi, Mykolenko; Stepanenko; Sudakov, Zinchenko; Tsygankov, Dovbyk, Mudryk.
Substitutes: Bushchan, Riznyk, Bondar, Sydorchuk, Malinovskyi, Yaremchuk, Sikan, Pikhalonok, Tymchyk, Zubkov, Dubinchak, Matviyenko.
Italy (possible 4-1-2-3) Donnarumma; Di Lorenzo, Acerbi, Buongiorno, Dimarco; Jorginho; Frattesi, Barella; Zaniolo, Raspadori, Chiesa.
Substitutes: Provedel, Vicario, Gatti, Biraghi, Bonavenutura, Scamacca, Kean, Darmian, Cristante, Politano, El Shaarawy, Mancini.
Referee Jesus Gil Manzano (Spain).