Four other senior players will not be appearing tonight either.
Cole Palmer, Wesley Fofana and Romeo Lavia were all left out to manage their fitness ahead of a busy season.
While Reece James remains injured, with Chelsea putting no timeline on his return.
But it could mean opportunities for fringe players like Marc Guiu, Carney Chukwuemeka and Cesare Casadei, as well as youngsters Josh Acheampong and Tyrique George.
What we know for a fact is that Ben Chilwell will not be starting tonight.
He was left out of Chelsea's Conference League squad as he tried to seal a deadline day exit.
Chilwell looked out of sorts when he came off the bench against Barrow last week.
And when Maresca was asked whether he regretted leaving the defender out of his European team, the Italian simply replied: "No."
Chelsea’s second string are no pushovers though.
The likes of Christopher Nkunku and Joao Felix will be hoping to start.
While Filip Jorgensen should get another go between the sticks.
And after battering Barrow 5-0 in the Carabao Cup, the backup Blues are sure to be feeling confident over their chances.
It may not be straightforward for Chelsea tonight.
Maresca already appears to have established his Premier League starting XI.
And we are likely to see a heavily-changed second team tonight.
Whether they can gel quickly remains to be seen.
And welcome to SunSport’s live coverage of Chelsea vs Gent.
Stamford Bridge will be rocking when the game kicks off at 8pm.
But can Enzo Maresca keep his fine run going?
Only time will tell, with team news in 15 minutes.