The main two long-term absentees for Real Madrid are Thibaut Courtois and David Alaba as they continue their rehabilitation from knee injuries.
Dani Ceballos is now training with the senior squad after being out injured so hope will be that he will soon be available for Carlo Ancelotti.
Eder Militao made a second appearance of the season as a late substitute on the weekend although the manager is likely not to rush him back into starting games just yet.
Vinicius Junior missed the game on the weekend due to suspension but will be available for the visit of Man City, with Brahim Diaz expected to make way for him.
Due to credible threats from terrorist groups, there will be an increased police presence for the game this evening.
While all welcome the move, we will be hoping there are no incidents in Spain.
The showpiece event will be watched all over the world and even the neutrals will not be wanting anything to tarnish what offers to be a monumental match-up.
Pep Guardiola has admitted he must "think about it" before deciding who to start in goal tonight.
Ederson could make his return from injury, replacing Stefan Ortega between the sticks for Manchester City.
Speaking ahead of the match, Guardiola explained: "I have to think about it. He [Ederson] feels good.
"Now I have to decide if a lack of rhythm for that match, I have to decide, but we are really pleased with the [performance] from Stefan Ortega. He is an exceptional keeper."
