Spain have also been in impressive form, winning six matches in a row heading into Friday's clash.
Luis de la Fuente has lost just one of his last 16 matches in charge, dating back to Scotland's surprise qualifying win in March 2023.
That defeat is one of just two in 19 matches since his appointment after the 2022 World Cup.
What is the team news and any injuries to worry about?
Germany will welcome Jonathan Tah back from suspension to face Spain.
The defender missed the win over Denmark after picking up two bookings during the group stage.
Elsewhere, there are no injury issues or suspensions for Nagelsmann to worry about.
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Jonathan Tah returns from suspension after missing Germany's win over DenmarkCredit: Getty
Spain are also free of any suspensions but could be without Aymeric Laporte through injury.
The 30-year-old is a doubt due to muscle fatigue and had struggled for fitness heading into the tournament.
However, a direct replacement is available with Nacho Fernandez now back to full fitness.
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Aymeric Laporte is an injury doubt for Spain heading into Friday's quarter-finalCredit: Getty
Who will be the star men?
Jamal Musiala has been the standout performer for the host nation so far this summer.
With his strike against Denmark, he now has three goals in four matches at Euro 2024.
That tally currently has Musiala level with Georges Mikautadze and Ivan Schranz as the joint top scorer, although his rivals have both been knocked out.
Spain have so far spread their goals across a devastating attack, although one player has shone through.
The 21-year-old winger grabbed a stunning goal and provided an assist against Georgia in the last 16 in his best performance of the tournament to date.
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What have the managers said?
Following Germany's win over Denmark, Nagelsmann admitted it will be tough for anyone to beat them when at their best.
He said: "There is always room to grow. Talk about the first 20 minutes in this game and it was very good, very happy with that.
"But we could speed up our game in ball possession. If we do like we did in the first 20 minutes it is really, really tough to beat us."
Meanwhile, De la Fuente acknowledged the meeting with Germany could easily have been the final.
Speaking after the last 16 win, he explained: "We know this next game could have been a final at a World Cup. It's a great rival we are going to face."
SunSport prediction
Recent meetings between Spain and Germany have been tight encounters, with three of the last four ending in 1-1 draws.
However, Spain romped to a 6-0 victory in 2020 and have been more impressive so far this summer.
The three-time winners are well worth their favourites tag.
SunSport prediction - 2-1
When is Spain vs Germany?
Spain vs Germany will take place TONIGHT, Friday, June5.
Kick off will be at 5pm BST.
The MHPArena in Stuttgart will host.
What TV channel is Spain vs Germany on and can it be live streamed FREE?
Spain vs Germany will be broadcast live on ITV1.
You can live stream the match for FREE on ITVX.
Alternatively, you can keep up to date with all the action by following SunSport's live blog.
German manager Nagelsmann told the media problems the Spanish wingers offer his team:
It's not a final, it's a quarter-final. We want to be one of the teams in the semi-final. Spain want to be champions as well, so it'll be a tough game. Both teams are good in possession, have good counter-pressing qualities and can put their opponents under pressure. Let's see how he reacts when things get tough. You can't defend him completely. You have to be prepared for different things. My focus is less on Yamal, more on Jamal [Musiala]. We can do something in attack ourselves.
Germany have looked in good form in Euro 2024, giving home fans hope that they can go on and win the trophy on home soil.
However, there is no doubting that Spain have looked the most impressive side in the tournament so far and if Nagelsmann is going to keep that dream alive they will need put in some performance this evening.
La Roja will provide the sternest test of the German defence and for the neutrals it offers to be the game of the Euros so far.
The pick of the quarter-finals takes place tonight as the hosts take on the favourites at the MHP Arena in Stuttgart.
Spain are expected to name an unchanged line-up for the game, with 16-year-old sensation Lamine Yamal and Athletic Bilbao star Nico Williams set to join Alvaro Morata in a three man attack.
Dani Olmo and Mikel Merino will be pushing for a start ahead of Pedri in the heart of midfield but the Barcelona man is expected to keep his place alongside Rodri and Fabian Ruiz.
Nacho has recovered from a minor foot injury but is unlikely to displace Le Normand or Aymeric Laporte in the centre of defence, while Dani Carvajal and Marc Cucurella should continue as full-backs.
Julian Nagelsmann could tinker with his side once again and may recall centre-back Jonathan Tah, who served a suspension in the last 16, at the expense of Nico Schlotterbeck.
Maximillian Mittelstadt was dropped against Denmark and will be looking to force his way back into the line-up ahead of David Raum, while Florian Wirtz could return on the left side of the attack at the expense of Leroy Sane, allowing Jamal Musiala to move over to the right.
Kai Havertz is expected to keep his spot as the central striker despite Niclas Fullkrug pushing for a place in Nagelsmann’s side.
