As many Man Utd bosses have been forced to do in the past, Amorim has turned to the Carrington Academy to bolster his thin senior squad.
Five youngsters - Sekou Kone,Harry Amass, Jack Moorhouse, Elyh Harrison and Chido Obi - have all travelled with the first team for the Premier League fixture.
With 11 stars now out injured, Amorim will be hoping the teenagers can provide an injection of energy to alleviate some of the pressure on the first team.
While Man Utd have been plunged into injury crisis, Spurs have been forced to deal with the consequences of injuries for most of the season.
Ange Postecoglou's side has been devastated by a seemingly unending convertor belt of stars heading to the treatment room.
However, this week things finally seem to be looking up as Spurs are set to welcome back three key stars to their squad.
The Aussie revealed that Guglielmo Vicario, Destiny Udogie and James Maddison were all fit enough to play a part in the fixture.
Meanwhile, Postecoglou also confirmed Brennan Johnson, Wilson Odobert and Timo Werner had all returned to training this week, though it is currently unclear whether they will play any part.