Enzo Maresca is likely to make wholesale changes from the side that lost their opening Premier League encounter to Manchester City.
However, Raheem Sterling will NOT feature having been left out of the European squad completely. Defenders Ben Chilwell, Wesley Fofana and Tosin Adarabioyo were also not included on Chelsea's A-list submitted to UEFA.
Chelsea clash with Swiss side Servette at Stamford Bridge tonight.
It's the first leg of their UEFA Conference League play-off round, and manager Enzo Maresca will be hopeful of a straightforward victory.
The Blues are overwhelming favourites at 1/10 to secure an advantage heading into next week's second leg in Geneva.
Should Chelsea triumph, they will advance to the new 36-team league stage, where each side faces six different teams and the top eight automatically qualify for the last 16.
Fatigue shouldn't be an issue following Sunday's 2-0 defeat to champions Manchester City given the size of Chelsea's squad.
It looks a good opportunity for the Italian manager, who is already favourite to be the first Premier League manager sacked this season, to get a win under his belt in front of home supporters.
Servette have lost three of their last five in all competitions, and were recently hammered 6-0 by Basel.