Mikel Arteta will be sweating over the fitness of William Saliba, with the Frenchman potentially missing for a third successive game due to a hamstring injury.
Myles Lewis-Skelly missed the midweek win over Dinamo Zagreb in the Champions League with a knee injury but could return this afternoon.
Ben White, Takehiro Tomiyasu, Bukayo Saka and Gabriel Jesus all remain out.
The Gunners return to Premier League action fresh from a 3-0 win over Dinamo Zagreb in the Champions League on Wednesday night.
Declan Rice, Kai Havertz and Martin Odegaard got on the scoresheet as the Gunners all but secured their spot in the last 16 of the competition.
Attention now quickly turns back to the Prem, with Arsenal six points behind leaders Liverpool, who have a game in hand.
They will be looking to pounce on a struggling Wolves side, who lost 3-1 to Wolves earlier this week.