Arsenal team news
Arsenal as well as having Declan Rice suspended, Martin Odegaard picked up a knock while away on international duty.
Arteta has hinted the Gunners captain could be included in the squad derby.
Meanwhile, Gabriel Jesus is expected to be back fit.
The Brazilian missed the past two Arsenal games due to a groin injury.
But Jesus has been back in training and hoping to be a part of Arteta's team this afternoon.
He said on Friday afternoon: “Gabi was out there [training]."
Spurs team news
Tottenham are set to have Dominic Solanke and Micky van de Ven back after they missed the 2-1 defeat at Newcastle before the international break.
It is still uncertain whether a late call will be made on Yves Bissouma after he picked up an issue with Mali on national team duty.
Ange Postecoglou said: "Micky's good, he's trained all the way through the international break so he's ready to go."
"Dom's improved as well and trained the back half of this week. We still have two days to go with those guys so hopefully they get through training OK and are available."
On Bissouma, Postecoglou added: "He's got a bit of an issue, but we'll have a look at him over the next couple of days and see how it settles."
What time is kick-off?
Today's historic North London derby will kick-off at 2pm BST.
Spurs will host the Gunners a the Tottenham Hotspur Stadium.
To watch this afternoon's actions fans can tune into Sky Sports Main Event, Sky Sports Premier League and Sky Sports Ultra HDR. Coverage starts at 1pm.
Alternatively, subscribers will be able to watch on a live stream via the Sky Go app.