No Dejan Kulusevski is a huge miss for Tottenham, with no ready-made replacement available to Ange Postecoglou due to James Maddison's injury.
The Aussie may opt to play Richarlison up top alongside Dominic Solanke with Son and Brennan Johnson on the flanks.
But we expect Wilson Odobert to play behind Solanke in the No10 role.
And it's a big one - Leny Yoro is set to START for Manchester United tonight.
The French defender went off injured in the Premier League defeat to West Ham just 10 days ago.
Few had predicted he would be back in time but the 19-year-old has got the nod for the final.
From SunSport's Dave Courtnadge at San Mames
Three hours to go in Bilbao and fans are starting to make their way to the stadium.
Of course, many are still making the most of the chance to have a drink, with no booze (alcohol-free, but that doesn't count) allowed in the stadium.
Despite all the Donkey Derby taunts of "El Crapico" slurs, fans here cannot wait for kick off.
This game means a lot to those who have made the often exhausting and usually expensive journey here, and the doubts about the abysmal form of both teams so far this season will mean nothing when it kicks off at 9pm here.
The majority have no idea what's going to happen, and anyone who makes a prediction does so with little conviction.
It's been a fantastic atmosphere so far with fans holding separate parties either side of this welcoming Basque city.
And when fans have mixed, it's all been good fun as far as I've seen in the two days I've been here.
But now the atmosphere is about to ramp up a notch as those 30,000 or so supporters with tickets head into the stadium dubbed "the Cathedral".
For those without tickets the parties will continue on the streets.
And for those who win, that party will be something like they've probably never seen before.
Leny Yoro was named in United's squad for the final, and should he be fit enough, we expect him to slot in for Victor Lindelof on the right side of the back three.
Ruben Amorim has a decision to make on who will join Bruno Fernandes in the Red Devils' front three, with Joshua Zirzkee back available and Rasmus Hojlund struggling for form.
Amad looks set to get the nod ahead of Alejandro Garnacho, but Amorim could opt to play both wingers and drop Fernandes into the midfield two in place of either Casemiro or Ugarte.
Man Utd have probably had the trickier of routes to the final, beating Real Sociedad and Lyon before knocking out final hosts Athletic Bilbao in the semis.
Spurs recorded narrow victories over AZ Alkmaar and Frankfurt in the last 16 and quarter-finals, respectively.
But Ange Postecoglou's men booked their spot in the final in style with a 5-1 aggregate win over Bodo/Glimt in the semis.
Manchester United were handed a triple boost with the returns of Diogo Dalot, Leny Yoro and Joshua Zirzee.
The trio were included in the Red Devils' matchday squad for tonight's Europa League final yesterday.
On the availability of the stars, Ruben Amorim said: "They recovered quite well, they pushed, of course we have to respect the feeling of the player, we pushed a little bit because they wanted to be part of the team.
"It's a very good sign. They are limited in the minutes (they can play) but they can help us to win the game."
Former Manchester United manager Erik ten Hag has reportedly not been invited to tonight's Europa League final.
The Dutchman led the Red Devils to the Europa League after winning the 2023/24 FA Cup.
Ten Hag was also in charge of three matches during United's league phase campaign, before he was sacked and replaced by Ruben Amorim last November.
It remains to be seen if Ten Hag, Ruud van Nistelrooy and Marcus Rashford will receive a medal for their involvement in the early part of the Europa League.
Unlike Ten Hag, Louis van Gaal was invited to the 2017 Europa League final, despite his sacking on the back of winning the FA Cup in 2016.
The position of Bruno Fernandes against a depleted Tottenham midfield is the key to Manchester United winning the Europa League.
Amorim has a conundrum - whether to play his skipper in one of the No10 positions or deeper in his midfield two.
United must trust Casemiro and Manuel Ugarte in the final so Fernandes can be used in a free role further up the pitch.
When he has played as one of the No10s, he is expected to run in-behind and stretch defences.
But this does not suit his game and, against Micky van de Ven, is a waste of time.
Amorim must ditch that and let his most complete player have freedom, drifting out the structure to give Spurs a headache.
SIX Premier League teams will be able to qualify for next season's Champions League!
UEFA awards the two leagues with the best set of collective results in European competitions with an extra Champions League spot.
And Arsenal's 3-0 quarter-final win over 15-time champions Real Madrid in April confirmed that the Premier League would get one of these spots.
Meaning that finishing fifth in the Prem would earn you a place in next year's Champions League.
But five qualification spots became six a couple of weeks back as Manchester United and Tottenham set up their Europa League final showdown in Bilbao.
This ensures that an English team will win the Europa League and therefore claim a place in Europe's premier competition next season.
Tottenham have been drawn as the home team for the Europa League final, which means they will wear their all-Lilywhite shirt with navy blue sleeves, paired with white shorts and white socks.
In domestic competitions, Spurs usually wear navy shorts, but due to a European tradition dating back to 1961, the North London outfit have opted for white shorts this evening.
Man Utd will don their red home shirts, but are forced to change their more customary white shorts.
The Red Devils will pair their iconic strip with black shorts and black socks - the same combination they wore in the last-16 away leg at Real Sociedad.
Spurs' goalkeeper will wear a yellow strip while Man Utd's shot stopper will be in all green.
Former Tottenham midfielder Sandro is on stage in the Spurs fan zone in Bilbao.
The Brazilian is belting out "glory, glory Tottenham Hotspur" to the delight of the faithful.
Can the North Londoners live up to the chant and claim glory this evening?
Manchester United players prepared for the Europa League final by getting fitted with £1,000 Paul Smith suits.
United have a long tradition of wearing smart outfits before a final, dating back to the glory days under Sir Alex Ferguson.
Last year they were suited and booted before winning the FA Cup against Manchester City.
And the Red Devils have now had new ones forged by bespoke tailoring outfit Paul Smith.
Their partnership dates back to 2008 and, according to the Paul Smith website, “is still going strong.”
Here are some shots of the thrilling match which saw Basque beat the UEFA legends on penalties ahead of tonight's final.
Can you spot some of your favourite players?
An Arsenal fan received a torrent of abuse after walking through Tottenham fans in Bilbao wearing a Gunners shirt.
Spurs supporters have taken over the Spanish city in preparation for the Europa League final.
Thousands are in Bilbao, many without tickets, and there is a party atmosphere with songs being sung and flares being set off.
One brave Arsenal fan decided to have some fun with a contingent of Tottenham fans, brazenly strolling through a crowd with an Gunners shirt on.
The Spurs fans reacted by abusing the supporter, singing: "W*****! W*****!W*****!"
This surely must have been a dare?!
Even more chaos from Tottenham fans in Bilabo.
This is shaping up to be some clash!
Felix Zwayer will be the man in the middle for TONIGHT'S huge Europa League final encounter between rivals Manchester United and Tottenham.
Here is everything you need to know about the referee who received a six-month ban for his involvement in a match-fixing scandal.
He made his Bundesliga debut in 2012 and soon become a regular fixture in their matches.
In 2005, his career took a hit when he found himself involved in a match-fixing scandal.
It was revealed that he accepted a €300 bribe from referee Robert Hoyzer, who was involved in a larger match-fixing scandal at the time in Germany.
Felix was banned from refereeing for six months by the German Football Association (DFB) as a result of his involvement.
If United do get the opportunity to rejoice in Europa League glory, the chiefs of the club are reportedly planning to celebrate with a barbecue instead.
However, the BBQ could be even less glamorous than it sounds - as major building work is taking place at Carrington.
It's understood the event - for players, staff and their families - would be the day after the final.
This will come as a real shame to United fans who haven't seen an open-top bus parade since the special occasion which heralded the Red Devils' 20th Prem title and the retirement of manager Sir Alex Ferguson after his golden reign of 27 years.
Manchester United fans are flocking to the food court and the names of the burgers are incredible!
Manchester United fans have been left devastated after finding out that there will be NO open-top bus parade should their club win the Europa League final - but there's an alternative plan.
After tonight's final, the Red Devils finish their Prem campaign at home to Aston Villa on Sunday week.
Then comes a gruelling 15-hour flight to Asia for money-spinning tour games in Kuala Lumpur and Hong Kong on May 28 and 30.
So United will have to wait longer for another open-top bus parade - having not held one since 2013.
United fans continue to flock the streets and make their voices heard ahead of tonight's Europa League final thriller.
You can barely tell what colour the sky is.
The Red Devils beat Ajax 2-0 in Stockholm eight years ago, courtesy of goals by Paul Pogba and Henrikh Mkhitaryan.
On that occasion they were managed by a Portuguese in Jose Mourinho, who had replaced a sacked FA Cup-winning Dutchman in Louis van Gaal.
Amorim is a Portuguese boss and replaced sacked Dutchman Ten Hag, who lifted the FA Cup last season...
Speaking of Mourinho, the former United boss won his first European trophy on May 21, 2003 - at the age of 40 years, three months and 24 days.
Tonight's final will also take place on May 21, with Amorim just one day younger than Mourinho was.
In addition to this, United's rivals Manchester City last went trophyless in 2017.
By losing to Palace on Saturday, Pep Guardiola's side were condemned to their first season without silverware since the 2016-17 campaign.
In March, Newcastle upset the odds to beat Liverpool in the Carabao Cup final - earning their first silverware since lifting the Inter-Cities Fairs Cup in 1969.
And just last week, Italian side Bologna won the Coppa Italia - beating AC Milan 1-0 in Rome to end a 51-year wait for a trophy.
Former Tottenham hero Harry Kane recently won the Bundesliga at the second time of asking, scoring 26 goals along the way to earning the first trophy of his career.
Most recently, Crystal Palace upset Manchester City in the FA Cup final to lift the first major silverware in their entire history.
It's been the season of fresh trophy winners - and Spurs will be hoping to join the party by earning their third Europa League triumph, having won its former iteration, the Uefa Cup, in 1971 and 1984.
