A UPS aircraft crashed after departing the Louisville Muhammad Ali International Airport in Kentucky, federal authorities said Tuesday.
There are reported injuries, according to the Louisville Metro Police Department, which did not specify how many.
Three crew members were on board the plane, according to UPS, which said it has not confirmed any injuries.
A shelter-in-place has been issued within 5 miles of the airport following the fiery crash, police said.
"This is an active scene with fire and debris. Stay away," the Louisville Metro Police Department said on social media.
UPS Flight 2976 crashed around 5:15 p.m. local time on Tuesday, according to the Federal Aviation Administration. The McDonnell Douglas MD-11 was headed to Daniel K. Inouye International Airport in Honolulu, the agency said.
It appears there was an engine issue during takeoff, sources told ABC News.
UPS said it has been "notified of an incident/accident involving one of our aircraft" in Louisville.
The airport is home to UPS Worldport, the company's massive package handling facility.
The FAA and the National Transportation Safety Board are investigating the crash.
A large plume of smoke could be seen near the airport, which is closed, according to the FAA.
The airport confirmed there was an "aircraft incident" and that the airfield is closed.
"Kentucky, we are aware of a reported plane crash near Louisville International Airport," Kentucky Gov. Andy Beshear said on social media. "First responders are onsite, and we will share more information as available. Please pray for the pilots, crew and everyone affected. We will share more soon."
Beshear said Tuesday evening that he is en route to Louisville.
"The situation is serious. Please pray for the families affected," he said.
ABC News' Luke Barr, Sam Sweeney and Ayesha Ali contributed to this report.
This is a developing story. Please check back for updates.